sns 032 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T17069	THAL-SNS-032		CDK
	THAL-SNS-032 is a selective CDK9 degrader PROTAC.		CDK
T6049	SNS-032	SNS032,BMS-387032	Apoptosis , GSK-3 , CDK
	SNS-032 (BMS-387032) is a selective inhibitor of CDK2 (IC50: 48 nM ) and is 10- and 20-fold selective over CDK1/CDK4. It is also sensitive to CDK7/9 (IC50: 62 nM/4 nM), and no effect on CDK6.		Apoptosis , GSK-3 , CDK
T79606	CAF-382		CDK
	CAF-382 (compound B1), an analog of SNS-032, functions as a CDKL5 and pan-CDK inhibitor, exhibiting modest inhibitory activity against GSK3α/β with an affinity greater than 1.8 μM. It effectively inhibits CDKL5 and imped...		CDK
T83936	LL-K9-3
	LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the...
T77959	Thalidomide-5-O-C12-NH2 hydrochloride
	Thalidomide-5-O-C12-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and, when linked to a ligand for protein, forms PROTACs [1].
T77984	Thalidomide-NH-C10-NH2 hydrochloride
	Thalidomide-NH-C10-NH2 hydrochloride, a thalidomide-derived cereblon ligand, facilitates CRBN protein recruitment and, when conjugated with a linker, forms PROTACs [1].
T77952	Thalidomide-5-O-C5-NH2 hydrochloride
	Thalidomide-5-O-C5-NH2 hydrochloride, a Thalidomide-derived cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated via a linker to form PROTACs [1].
T77950	Thalidomide-5-O-C3-NH2 hydrochloride
	Thalidomide-5-O-C3-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates CRBN protein recruitment and can be conjugated to a protein ligand via a linker to synthesize PROTACs [1].
T77962	Thalidomide-4-O-C11-NH2 hydrochloride
	Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-based cereblon ligand for CRBN protein recruitment. It can be conjugated to a protein ligand via a linker to create PROTACs [1].
T77977	Thalidomide-5-PEG6-NH2 hydrochloride
	Thalidomide-5-PEG6-NH2 hydrochloride, a Thalidomide-derived cereblon ligand, facilitates the recruitment of the CRBN protein and can be tethered to a ligand for protein conjugation via a linker to construct PROTACs [1].
T77958	Thalidomide-5-O-C11-NH2 hydrochloride
	Thalidomide-5-O-C11-NH2 hydrochloride, a thalidomide-derived cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated to a protein ligand via a linker to synthesize PROTACs [1].
T77978	Thalidomide-5-PEG7-NH2 hydrochloride
	Thalidomide-5-PEG7-NH2 hydrochloride is a Thalidomide-based cereblon ligand employed for CRBN protein recruitment. It can be conjugated to a protein ligand using a linker to create PROTACs [1].
T77957	Thalidomide-5-O-C10-NH2 hydrochloride
	Thalidomide-5-O-C10-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and, when linked to a protein ligand, forms PROTACs [1].
T77964	Thalidomide-4-O-C14-NH2 hydrochloride
	Thalidomide-4-O-C14-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and, through the attachment of a linker, can be utilized to create PROTACs [1].
T77954	Thalidomide-5-O-C7-NH2 hydrochloride
	Thalidomide-5-O-C7-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates CRBN protein recruitment. This compound can be tethered to a protein-targeting ligand using a linker, enabling the formation of PROTA...
T77963	Thalidomide-4-O-C12-NH2 hydrochloride
	Thalidomide-4-O-C12-NH2 hydrochloride is a cereblon ligand based on Thalidomide, utilized for recruiting the CRBN protein. This compound can be tethered to a protein ligand using a linker, enabling the formation of PROTA...
T77919	Thalidomide-4-O-C10-NH2 hydrochloride
	Thalidomide-4-O-C10-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of the CRBN protein. This compound can be conjugated with a protein ligand via a linker to synthesize PROTACs [1].
T77917	Thalidomide-4-O-C7-NH2 hydrochloride
	Thalidomide-4-O-C7-NH2 hydrochloride, a Thalidomide-based cereblon ligand, plays a role in the recruitment of CRBN protein and, when linked to a protein ligand, forms PROTACs [1].
T77949	Thalidomide-5-O-C2-NH2 hydrochloride
	Thalidomide-5-O-C2-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated via a linker to form PROTACs [1].
T77961	Thalidomide-5-O-C14-NH2 hydrochloride
	Thalidomide-5-O-C14-NH2 hydrochloride, a cereblon ligand based on Thalidomide, facilitates the recruitment of CRBN protein. By incorporating a linker, this compound can be conjugated to a ligand to create PROTACs [1].